The "Smoke and Heat Ready Communities Act of 2025" authorizes the EPA Administrator to award grants to air pollution control agencies for programs that help communities prepare for and lessen the impacts of wildfire smoke and extreme heat. It establishes Centers of Excellence for research on the public health effects of these events and directs the Administrator to conduct further research and develop interventions. The Act also creates a grant program for states, local governments, Indian Tribes, and Native Hawaiian organizations to develop and implement community plans to reduce the effects of wildfire smoke and extreme heat.