The Joint Task Force to Counter Illicit Synthetic Narcotics Act of 2025 establishes a high-level, multi-agency task force (JTFISN) to coordinate and lead federal efforts against the illicit synthetic narcotics crisis. This task force will focus on disrupting trafficking networks, enforcing sanctions, and improving intelligence sharing across departments like Justice, Treasury, and Homeland Security. The Director will report to the Attorney General and Congress, providing regular updates on enforcement actions and strategies, particularly those targeting foreign actors like the People's Republic of China. Crucially, the law explicitly prohibits the task force from targeting individual drug users or low-level dealing unrelated to major trafficking operations.